International Number: 0032 2 403 72 26

Bacterial cell biology explored with state-of-the art techniques

At the Department of Microbiology, Ludwig-Maximilians University Munich, Prof. Dr. Marc Bramkamp tackles fundamental questions in bacterial cell biology.

Our group is using the model organisms Bacillus subtilis and Corynebacterium glutamicum to unravel principal mechanisms of growth and subcellular organization of rod-shaped bacteria. These fundamental questions in bacterial cell biology are tackled with state-of-the art techniques such as live cell imaging, in vitro reconstitution and protein-protein or protein-DNA interaction studies.

Bacterial Cell Biology Research

Cytokinesis is a prerequisite for cellular life. Therefore, it is not surprising that the process of cell division is tightly controlled and intimately linked to other key cellular processes such as genome replication. Understanding the molecular mechanisms behind cytokinesis revealed fascinating insights in the subcellular organization of eukaryotic and prokaryotic cells.

Our lab is devoted to understand how Gram positive, rod-shaped bacteria, such as Bacillus subtilis and Corynebacterium glutamicum, are accomplishing cell division and how this process is regulated in time and space.

Bacillus subtilis

Bacillus subtilis is an excellent model organism to investigate cell developmental processes and subcellular organization. We investigate how the plasma membrane is organized in functional subdomains, how cells respond to environmental stresses such as antimicrobial compounds and how cytokinesis is spatially regulated in these cells. To get detailed insight into the assembly of protein machineries involved in these processes, we employ multicolor photo-activated localization microscopy (PALM). This technique allows imaging with unrivaled resolution.   more

Corynebacterium glutamicum

Corynebacterium glutamicum is a rod shaped Gram positive actinomycete that is widely used in the industrial amino acid fermentation.

Furthermore, the close relationship to several pathogenic organisms such as Corynebacterium diphtheriae and Mycobacterium tuberculosis opens several interesting cell biological tasks. We are interested in the interplay and mechanisms of proteins regulating chromosome segregation, cell elongation and division.   more

You can also follow us on Twitter for further updates on: @BramkampLab

bacterial cell biology

For more information, visit:

www.bacteriology.bio.lmu.de

 

Address

Ludwig-Maximilians-Universität München
Biozentrum
Department I, Bereich Mikrobiologie
AG Bramkamp
Großhaderner Straße 2-4
82152 Planegg – Martnsried

 

Phone

Prof. Bramkamp:

+49 (0)89 / 2180-74611
Dr. Karin Schubert:

+49 (0)89 / 2180-74612
PhD office I:

+49 (0)89 / 2180-74613
PhD office II:

+49 (0)89 / 2180-74614
Main lab:

+49 (0)89 / 2180-74618

 

Email

marc.bramkamp@lmu.de