Bacterial cell biology explored with state-of-the art techniques
At the Department of Microbiology, Ludwig-Maximilians University Munich, Prof. Dr. Marc Bramkamp tackles fundamental questions in bacterial cell biology.
Our group is using the model organisms Bacillus subtilis and Corynebacterium glutamicum to unravel principal mechanisms of growth and subcellular organization of rod-shaped bacteria. These fundamental questions in bacterial cell biology are tackled with state-of-the art techniques such as live cell imaging, in vitro reconstitution and protein-protein or protein-DNA interaction studies.
Bacterial Cell Biology Research
Cytokinesis is a prerequisite for cellular life. Therefore, it is not surprising that the process of cell division is tightly controlled and intimately linked to other key cellular processes such as genome replication. Understanding the molecular mechanisms behind cytokinesis revealed fascinating insights in the subcellular organization of eukaryotic and prokaryotic cells.
Our lab is devoted to understand how Gram positive, rod-shaped bacteria, such as Bacillus subtilis and Corynebacterium glutamicum, are accomplishing cell division and how this process is regulated in time and space.
Bacillus subtilis is an excellent model organism to investigate cell developmental processes and subcellular organization. We investigate how the plasma membrane is organized in functional subdomains, how cells respond to environmental stresses such as antimicrobial compounds and how cytokinesis is spatially regulated in these cells. To get detailed insight into the assembly of protein machineries involved in these processes, we employ multicolor photo-activated localization microscopy (PALM). This technique allows imaging with unrivaled resolution. more
Corynebacterium glutamicum is a rod shaped Gram positive actinomycete that is widely used in the industrial amino acid fermentation.
Furthermore, the close relationship to several pathogenic organisms such as Corynebacterium diphtheriae and Mycobacterium tuberculosis opens several interesting cell biological tasks. We are interested in the interplay and mechanisms of proteins regulating chromosome segregation, cell elongation and division. more
You can also follow us on Twitter for further updates on: @BramkampLab
For more information, visit:
Department I, Bereich Mikrobiologie
Großhaderner Straße 2-4
82152 Planegg – Martnsried
+49 (0)89 / 2180-74611
Dr. Karin Schubert:
+49 (0)89 / 2180-74612
PhD office I:
+49 (0)89 / 2180-74613
PhD office II:
+49 (0)89 / 2180-74614
+49 (0)89 / 2180-74618